Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 90
Amount Per Serving
%DV
Nattokinase(from fibrinase enzyme)
2,000 FU**
†
Top Medical Research Studies
9.5
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Read More
8
We designed a study to explore the effectiveness of nattokinase in treating acute myocardial infarction, a condition often caused by blood clots. Thrombus formation leads to reduced blood flow, and finding effective treatments is critical for improving outcomes in heart attack patients.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Read More
Most Useful Reviews
9
Significant heart issue relief
76 people found this helpful
It works wonderfully for my clogged veins and arteries! I combine this with serrapeptase, unsure which is more effective but committed to both. Suffering from severe type 2 diabetes, I previously faced heart spasms that were quite alarming, making me fear a heart attack was imminent. After taking Nattokinase, my heart problems vanished within two days! Unlikely coincidence, this supplement has offered the most noticeable results of any I've tried.
Read More
9
No more blood thinner issues
8 people found this helpful
Great! I have been using this product for a few months, following my doctor's recommendation to take two a day after discontinuing Plavix, which I used post-heart attack to thin my blood. These work incredibly well, and I've experienced no issues whatsoever while finally being off Plavix! I continue taking Aspirin daily but without the negative side effects I had from Plavix. I highly recommend this product!
Read More
9
Steady improvement noted
285 people found this helpful
This product is beneficial for some individuals. I felt compelled to review "Doctor's Best Nattokinase (2,000 Fu)" due to the significant improvement my family has experienced over the last two years. My father had a heart attack two and a half years ago, and after thorough research, we decided to try Nattokinase for additional support alongside traditional treatments. After a year of daily intake, his ECG results improved significantly, which the doctor confirmed as a good sign. I've also benefited, as my blood pressure decreased considerably without additional medications. However, it’s crucial to consult a doctor before starting this supplement.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
- All Researches
9.5
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Read More
8
We designed a study to explore the effectiveness of nattokinase in treating acute myocardial infarction, a condition often caused by blood clots. Thrombus formation leads to reduced blood flow, and finding effective treatments is critical for improving outcomes in heart attack patients.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant heart issue relief
76 people found this helpful
It works wonderfully for my clogged veins and arteries! I combine this with serrapeptase, unsure which is more effective but committed to both. Suffering from severe type 2 diabetes, I previously faced heart spasms that were quite alarming, making me fear a heart attack was imminent. After taking Nattokinase, my heart problems vanished within two days! Unlikely coincidence, this supplement has offered the most noticeable results of any I've tried.
Read More
9
No more blood thinner issues
8 people found this helpful
Great! I have been using this product for a few months, following my doctor's recommendation to take two a day after discontinuing Plavix, which I used post-heart attack to thin my blood. These work incredibly well, and I've experienced no issues whatsoever while finally being off Plavix! I continue taking Aspirin daily but without the negative side effects I had from Plavix. I highly recommend this product!
Read More
9
Steady improvement noted
285 people found this helpful
This product is beneficial for some individuals. I felt compelled to review "Doctor's Best Nattokinase (2,000 Fu)" due to the significant improvement my family has experienced over the last two years. My father had a heart attack two and a half years ago, and after thorough research, we decided to try Nattokinase for additional support alongside traditional treatments. After a year of daily intake, his ECG results improved significantly, which the doctor confirmed as a good sign. I've also benefited, as my blood pressure decreased considerably without additional medications. However, it’s crucial to consult a doctor before starting this supplement.
Read More
7.5
Reduced reliance on medications
47 people found this helpful
I think everyone over a certain age should consider this product. I experienced a severe attack with AFib about a year and a half ago, landing me in ICU. Despite being advised to take blood thinners daily, I sought natural alternatives and discovered Nattokinase. It has helped with my heart and blood flow issues, and I feel a noticeable improvement shortly after taking it. Many others have successfully switched from blood thinners to this supplement, avoiding the side effects of medications.
Read More
6
Supports recovery efforts
18 people found this helpful
This is not Shawn, but his wife. I looked into this product after my mother had a mild stroke. A dear friend suggested it alongside Serrapeptase for cholesterol removal. It supports recovery while making dietary changes and exercising. However, caution is needed for those on blood thinners, as it could pose risks. For anyone considering this for themselves or loved ones, remember that recovery takes time.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763
- Chandrasekaran SD, Vaithilingam M, Shanker R, Kumar S, Thiyur S, et al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015;8:e23567. doi:10.5812/jjm.23567
